Practical Application Corner – Journal Club.

Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

The benefit of the addition of perioperative pembrolizumab to standard care with surgery and adjuvant therapy for patients with locally advanced head and neck squamous-cell carcinoma (HNSCC) is unclear.

Tumor-Infiltrating Clonal Hematopoiesis

Reveals that clonal hematopoiesis mutations within tumor microenvironments worsen outcomes — uniting hematology and solid tumor biology.

Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy

DLL3-targeted bispecific T-cell engager delivers the first real survival breakthrough in SCLC in decades — new benchmark for immuno-engagers.

Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer

Transforms a historically lethal subset into a treatable disease with targeted triplet therapy; establishes new first-line standard.

Nonoperative Management of Mismatch Repair-Deficient Tumors

Immunotherapy replaces surgery for localized dMMR cancers — a paradigm shift proving organ preservation with 100% complete response rate.

How Close Are We to Achieving Durable and Efficacious Gene Therapy for Hemophilia A and B?

Extended follow-up of pegcetacoplan and new oral factor D inhibitors confirms near-complete hemolysis control with improved quality of life.

Advancements in complement inhibition for PNH and primary complement–mediated thrombotic microangiopathy

Long-term data showing sustained endogenous FVIII expression and reduced annualized bleed rates; establishes gene therapy as durable disease modification.

Can Early Intervention Prevent Leukemia? New Trial Gives Patients a Choice Beyond the Current ‘Wait and See’ Approach

Prospective cohort demonstrating that targeted anti-inflammatory therapy in high-risk CHIP carriers reduces progression to AML/MDS. Bridges genomics, inflammation, and prevention.